A research team from Cincinnati Children’s Hospital Medical Center has received a grant to identify new subtypes of cancer through variations in gene splicing. The group, led by Nathan Salomonis, PhD of the Division of Biomedical Informatics, will apply novel computational approaches to define the genetics of diverse cancers.  

Image of Nathan Salomonis
Nathan Salomonis, PhD, of Cincinnati Children’s has won a $1.4 million NIH grant to study the impact of splicing variation in cancers.

Funding comes from a National Institutes of Health (NIH) Independent Investigator Award received by Salomonis. The award totals $1.4 million and runs from July 2018-June 2023.

Members of the Salomonis lab (Meenakshi Venkatasubramanian, Aishwarya Kulkarni, Stuart Hay, Kashish Chetal, Erica DePasquale, and Kenneth Eaton) and the Matthew Weirauch, PhD lab (Xiaoting Chen, Kevin Ernst) will receive funding through the grant.

The team has already generated preliminary results using these new computational tools, including new subtypes of cancer that are uniquely associated with splicing and patient survival. They are working to identify novel subtypes of cancers associated with splicing along with underlying genetic factors, clinical relevance and candidate regulators to be tested in orthogonal research studies.

From this work, the Salomonis team aims to build a new web-based discovery platform for precision splicing biomarker detection and selective splicing target inhibition. By integrating splicing, gene expression, proteomics, and methylation data from the same patients into a computational interface, splicing events will be linked to known cancer pathways.

For more information, contact Nathan Salomonis at nathan.salomonis@cchmc.org.

Image of the Salomonis Lab
The Salomonis lab staff (from left): Meenakshi Venkatasubramanian, Erica DePasquale, Nathan Salomonis, Kenneth Eaton, Aishwarya Kulkarni and Kashish Chetal. Not pictured: Stuart Hay.



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